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Closed-loop lumped parameter modelling of hemodynamics during cirrhogenesis in rats
- Source :
- IEEE Transactions on Biomedical Engineering, IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers, In press, ⟨10.1109/TBME.2018.2793948⟩, IEEE Transactions on Biomedical Engineering, In press, ⟨10.1109/TBME.2018.2793948⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- Objective: Cirrhosis is the common end-stage of any given chronic liver disease, developing after persistent destruction and regeneration of parenchymal liver cells. The associated architectural distortion increases the intrahepatic vascular resistance, leading to portal hypertension and systemic circulatory disorders. This study investigates the impact of the changing vascular resistances on the hepatic and global circulation hemodynamics during cirrhogenesis. Methods: Cirrhogenesis was revisited using the thioacetamide rat model (N = 20). Rats were sacrificed at weeks 0, 6, 12, and 18. For each time-point 3D vascular geometries were created by combining hepatic vascular corrosion casting with µCT imaging. Morphological quantification of the trees branching topology provided the input for a lobe-specific lumped parameter model of the liver that was coupled to a closed-loop model of the entire circulation of the rat. Hemodynamics were simulated in physiological and pathological circumstances. Results: The simulations showed the effect of the liver vascular resistances (driven by the hepatic venous resistance increase) on liver hemodynamics with portal hypertension observed after 12 weeks. The closed-loop model was further adapted to account for systemic circulatory compensation mechanisms and disorders frequently observed in cirrhosis and simulated their impact on the hepatic, systemic and pulmonary hemodynamics. Conclusion: The simulations explain how vascular changes due to cirrhosis severely disrupt both hepatic and global hemodynamics. Significance: This study is a priori the first to model the rat entire blood circulation during cirrhogenesis. Since it is able to simulate cirrhosis main characteristics, the model may be translated to humans for the assessment of liver interventions ispartof: IEEE Transactions on Biomedical Engineering vol:65 issue:10 pages:2311-2322 ispartof: location:United States status: published
- Subjects :
- Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
0206 medical engineering
Biomedical Engineering
Hemodynamics
02 engineering and technology
Corrosion Casting
Chronic liver disease
03 medical and health sciences
chemistry.chemical_compound
Imaging, Three-Dimensional
0302 clinical medicine
Internal medicine
Parenchyma
medicine
Animals
Computer Simulation
Rats, Wistar
[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph]
Closed-loop lumped parameter modelling
business.industry
Models, Cardiovascular
Systemic disorders
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
X-Ray Microtomography
medicine.disease
020601 biomedical engineering
[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Rats
medicine.anatomical_structure
chemistry
Circulatory system
Liver cirrhogenesis
Vascular resistance
Cardiology
Portal hypertension
Thioacetamide
business
Vascular corrosion casting
030217 neurology & neurosurgery
Liver Circulation
Subjects
Details
- Language :
- English
- ISSN :
- 00189294
- Database :
- OpenAIRE
- Journal :
- IEEE Transactions on Biomedical Engineering, IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers, In press, ⟨10.1109/TBME.2018.2793948⟩, IEEE Transactions on Biomedical Engineering, In press, ⟨10.1109/TBME.2018.2793948⟩
- Accession number :
- edsair.doi.dedup.....252c460e7a2d4ef0515fb2b566595b9d