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Corrected QT interval in hospitalized patients with coronavirus disease 2019
- Source :
- Medicine
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Corrected QT (QTc) interval prolongation has been associated with poor patient prognosis. In this study, we assessed the effects of different drugs and cardiac injury on QTc interval prolongation in patients with coronavirus disease 2019 (COVID-19).The study cohort consisted of 395 confirmed COVID-19 cases from the Wuhan Union Hospital West Campus. All hospitalized patients were treated with chloroquine/hydroxychloroquine (CQ/HCQ), lopinavir/ritonavir (LPV/r), quinolones, interferon, Arbidol, or Qingfei Paidu decoction (QPD) and received at least 1 electrocardiogram after drug administration.Fifty one (12.9%) patients exhibited QTc prolongation (QTcâ≥â470âms). QTc interval prolongation was associated with COVID-19 severity and mortality (both Pâ
- Subjects :
- Male
cardiac injury
Indoles
Quinolones
corrected QT prolongation
Severity of Illness Index
Gastroenterology
Lopinavir
Electrocardiography
qingfei Paidu decoction
Odds Ratio
Medicine
Hospital Mortality
Chloroquine
General Medicine
Middle Aged
Hospitalization
Long QT Syndrome
cardiovascular system
Drug Therapy, Combination
Female
Research Article
medicine.drug
medicine.medical_specialty
hydroxychloroquine
Long QT syndrome
Observational Study
Antiviral Agents
QT interval
antiviral drugs
coronavirus disease 2019
Internal medicine
Severity of illness
Humans
cardiovascular diseases
Aged
Retrospective Studies
Ritonavir
SARS-CoV-2
business.industry
COVID-19
Hydroxychloroquine
Odds ratio
medicine.disease
Confidence interval
COVID-19 Drug Treatment
Interferons
business
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 15365964 and 00257974
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....2529d8b7420f1ec872ebea504033fecf