Back to Search
Start Over
Usefulness and correlation with clinical response of serum ustekinumab levels measured at 6 weeks versus 12 weeks
- Source :
- Journal of Dermatological Treatment, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, instname
- Publication Year :
- 2018
-
Abstract
- Background: Monitoring serum drug levels has been proposed as a useful tool for improving and personalizing the management of psoriasis. However, in the case of ustekinumab the usefulness of such monitoring was not demonstrated when drug levels were measured at week 12. Objectives: To evaluate the correlation of serum ustekinumab levels measured at weeks 6 and 12 with clinical response. Methods: In a prospective cohort study, we enrolled patients with psoriasis treated with ustekinumab 45 mg every 12 weeks for at least 24 weeks. We measured serum ustekinumab levels at weeks 6 and 12 in each patient. Using the absolute PASI score, response to treatment was defined as optimal (3 and 5). Results: About 54 serum samples from 27 patients were analyzed. No correlation was found between serum drug levels and absolute PASI at week 12. At week 6, an inverse linear correlation was found (p = .0001). Moreover, serum levels at week 6 were higher in patients with optimal, excellent and appropriate responses than in patients with an inappropriate response. Conclusions: Assessment of ustekinumab serum levels at week 6 could provide useful information in routine clinical practice.
- Subjects :
- Adult
Male
medicine.medical_specialty
Dermatology
Severity of Illness Index
ustekinumab
Drug levels
Correlation
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Psoriasis
Internal medicine
Ustekinumab
medicine
Humans
biologic therapy
Prospective Studies
030203 arthritis & rheumatology
business.industry
Middle Aged
medicine.disease
trough serum levels
Treatment Outcome
Female
Dermatologic Agents
Drug Monitoring
business
medicine.drug
Subjects
Details
- ISSN :
- 14711753 and 09546634
- Volume :
- 30
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of dermatological treatment
- Accession number :
- edsair.doi.dedup.....2524d4d29859af25387b06781a75462b