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Comparing the Therapeutic Effects of Aloe vera and Olive Oil Combination Cream versus Topical Betamethasone for Atopic Dermatitis: A Randomized Double-blind Clinical Trial
- Source :
- Journal of Pharmacopuncture, Vol 23, Iss 3, Pp 173-178 (2020)
- Publication Year :
- 2020
- Publisher :
- Korean Pharmacopuncture Institute, 2020.
-
Abstract
- Objectives: Atopic dermatitis (AD) is a prevalent and chronic, pruritic inflammatory skin condition that can influence all age groups. AD is associated with a poor health-related quality of life. This randomized clinical trial was performed to compare the effectiveness of Olivederma (combination of aloe vera and virgin olive oil) or betamethasone regarding disease severity, quality of life, serum IgE and eosinophil count. Methods: Thirty-six AD patients were randomly allocated to topical Olivederma or betamethasone, and were followed for 6 weeks. Results: Total SCORAD severity scores showed significant decrease in both groups, while it was more prominent in Olivederma group (64.5% improvement in Olivederma vs. 13.5% improvement in Betamethasone, p-value < 0.001). Quality of life (DLQI questionnaire) of AD patients was significantly improved after 6 weeks treatment with Betamethasone (22.3%, p < 0.001) and Olivederma (60.7%, p-value < 0.001). Olivederma group showed a significantly lower DLQI score in comparison with Betamethasone treated patients after 6 weeks of therapy (p < 0.001). Improvements in eosinophil count and serum IgE was observed. Conclusion: In summary, this study shows that Olivederma is superior to topical Betamethasone after 6 weeks of therapy with regard to disease severity, quality of life and eosinophil count.
- Subjects :
- medicine.medical_specialty
corticosteroid
040301 veterinary sciences
medicine.drug_class
lcsh:Medicine
Gastroenterology
Aloe vera
law.invention
0403 veterinary science
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
SCORAD
lcsh:Miscellaneous systems and treatments
Pharmacology
medicine.diagnostic_test
biology
atopic dermatitis
business.industry
Therapeutic effect
lcsh:R
lcsh:RM1-950
04 agricultural and veterinary sciences
Atopic dermatitis
topical administration
medicine.disease
biology.organism_classification
olive oil
lcsh:RZ409.7-999
Clinical trial
lcsh:Therapeutics. Pharmacology
Complementary and alternative medicine
aloe vera
Betamethasone
Corticosteroid
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20936966
- Volume :
- 23
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacopuncture
- Accession number :
- edsair.doi.dedup.....25204fe4c69d08919aeca6099092daf0