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Gray matter abnormalities in Tourette Syndrome: a meta-analysis of voxel-based morphometry studies
- Source :
- Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021), Translational Psychiatry
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Tourette syndrome (TS) is a neurobehavioral disorder for which the neurological mechanism has not been elucidated. Voxel-based morphometry (VBM) studies have revealed abnormalities in gray matter volume (GMV) in patients with TS; however, consistent results have not been obtained. The current study attempted to provide a voxel wise meta-analysis of gray matter changes using seed-based d mapping (SDM). We identified ten relevant studies that investigated gray matter alterations in TS patients and performed a meta-analysis using the SDM method to quantitatively estimate regional gray matter abnormalities. Next, we examined the relationships between GMV abnormalities and demographic and clinical characteristics. Our results demonstrated that TS patients had smaller GMV in the bilateral inferior frontal gyri and greater GMV in the cerebellum, right striatum (putamen), and bilateral thalami (pulvinar nucleus) than healthy controls. A meta-regression analysis did not identify correlations between GMV changes and demographic or clinical variables. This meta-analysis confirmed significant and consistent GMV changes in several brain regions of TS patients, primarily in the cortico-striato-thalamo-cortical network.
- Subjects :
- Cerebellum
Pulvinar nuclei
Prefrontal Cortex
Diseases
Neurosciences. Biological psychiatry. Neuropsychiatry
computer.software_genre
Tourette syndrome
Article
Cellular and Molecular Neuroscience
Voxel
medicine
Humans
Gray Matter
Prefrontal cortex
Biological Psychiatry
medicine.diagnostic_test
business.industry
Putamen
Brain
Magnetic resonance imaging
Voxel-based morphometry
Anatomy
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
medicine.anatomical_structure
nervous system
business
computer
Neuroscience
Tourette Syndrome
RC321-571
Subjects
Details
- ISSN :
- 21583188
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Translational Psychiatry
- Accession number :
- edsair.doi.dedup.....251c4745e9b8863c38907aa2c400ce3b