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Diagnostic Power of Longitudinal Strain at Rest for the Detection of Obstructive Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus
- Source :
- Ultrasound in Medicine & Biology. 41:89-98
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Global longitudinal strain (GLS) measured by 2-D speckle-tracking echocardiography (2-D STE) at rest has been recognized as a sensitive parameter in the detection of significant coronary artery disease (CAD). However, the diagnostic power of 2-D STE in the detection of significant CAD in patients with diabetes mellitus is unknown. Two-dimensional STE features were studied in total of 143 consecutive patients who underwent echocardiography and coronary angiography. Left ventricular global and segmental peak systolic longitudinal strains (PSLSs) were quantified by speckle-tracking imaging. In the presence of obstructive CAD (defined as stenosis ≥75%), global PSLS was significantly lower in patients with diabetes mellitus than in patients without (16.65 ± 2.29% vs. 17.32 ± 2.27%, p < 0.05). Receiver operating characteristic analysis revealed that global PSLS could effectively detect obstructive CAD in patients without diabetes mellitus (cutoff value: -18.35%, sensitivity: 78.8%, specificity: 77.5%). However, global PSLS could detect obstructive CAD in diabetic patients at a lower cutoff value with inadequate sensitivity and specificity (cutoff value: -17.15%; sensitivity: 61.1%, specificity: 52.9%). In addition, the results for segmental PSLS were similar to those for global PSLS. In conclusion, global and segmental PSLSs at rest were significantly lower in patients with both obstructive CAD and diabetes mellitus than in patients with obstructive CAD only; thus, PSLSs at rest might not be a useful parameter in the detection of obstructive CAD in patients with diabetes mellitus.
- Subjects :
- Male
medicine.medical_specialty
Acoustics and Ultrasonics
Longitudinal strain
Biophysics
Sensitivity and Specificity
Coronary artery disease
Elastic Modulus
Internal medicine
Diabetes mellitus
Humans
Medicine
Cutoff
Radiology, Nuclear Medicine and imaging
In patient
Rest (music)
Radiological and Ultrasound Technology
business.industry
Coronary Stenosis
Reproducibility of Results
Type 2 Diabetes Mellitus
Middle Aged
medicine.disease
Stenosis
Diabetes Mellitus, Type 2
Echocardiography
Cardiology
Anisotropy
Elasticity Imaging Techniques
Female
Stress, Mechanical
business
Subjects
Details
- ISSN :
- 03015629
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Ultrasound in Medicine & Biology
- Accession number :
- edsair.doi.dedup.....250b030c38313c316d0eaee88bc80b2f
- Full Text :
- https://doi.org/10.1016/j.ultrasmedbio.2014.08.011