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Diagnostic Power of Longitudinal Strain at Rest for the Detection of Obstructive Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus

Authors :
Wen-yu Li
Houjuan Zuo
Pengcheng Li
Hesong Zeng
Zhengxiang Liu
Hong Wang
Jiangtao Yan
Jiagao Lv
Dao Wen Wang
Guanglin Cui
Source :
Ultrasound in Medicine & Biology. 41:89-98
Publication Year :
2015
Publisher :
Elsevier BV, 2015.

Abstract

Global longitudinal strain (GLS) measured by 2-D speckle-tracking echocardiography (2-D STE) at rest has been recognized as a sensitive parameter in the detection of significant coronary artery disease (CAD). However, the diagnostic power of 2-D STE in the detection of significant CAD in patients with diabetes mellitus is unknown. Two-dimensional STE features were studied in total of 143 consecutive patients who underwent echocardiography and coronary angiography. Left ventricular global and segmental peak systolic longitudinal strains (PSLSs) were quantified by speckle-tracking imaging. In the presence of obstructive CAD (defined as stenosis ≥75%), global PSLS was significantly lower in patients with diabetes mellitus than in patients without (16.65 ± 2.29% vs. 17.32 ± 2.27%, p < 0.05). Receiver operating characteristic analysis revealed that global PSLS could effectively detect obstructive CAD in patients without diabetes mellitus (cutoff value: -18.35%, sensitivity: 78.8%, specificity: 77.5%). However, global PSLS could detect obstructive CAD in diabetic patients at a lower cutoff value with inadequate sensitivity and specificity (cutoff value: -17.15%; sensitivity: 61.1%, specificity: 52.9%). In addition, the results for segmental PSLS were similar to those for global PSLS. In conclusion, global and segmental PSLSs at rest were significantly lower in patients with both obstructive CAD and diabetes mellitus than in patients with obstructive CAD only; thus, PSLSs at rest might not be a useful parameter in the detection of obstructive CAD in patients with diabetes mellitus.

Details

ISSN :
03015629
Volume :
41
Database :
OpenAIRE
Journal :
Ultrasound in Medicine & Biology
Accession number :
edsair.doi.dedup.....250b030c38313c316d0eaee88bc80b2f
Full Text :
https://doi.org/10.1016/j.ultrasmedbio.2014.08.011