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Does conversion of immunosuppressive monotherapy from cyclosporine a to tacrolimus improve bone mineral density in long-term stable liver transplant recipients?
- Source :
- Transplantation Proceedings. 35:3032-3034
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- The effects of converting cyclosporine A to tacrolimus on bone mineral density (BMD) have not yet been evaluated thoroughly in liver transplant patients. Interfering factors in this patient population often are concomitant glucocorticoid treatment or exposure to estrogens. Here, we investigated in a homogeneous population of 10 male liver transplant recipients the impact of converting low-dose cyclosporine A monotherapy to low-dose tacrolimus monotherapy on BMD by using dual-energy x-ray absorptiometry. During the 12-month study period, an increase in BMD at the lumbar spine was observed in 9 out of 10 men (P
- Subjects :
- Male
musculoskeletal diseases
medicine.medical_specialty
Time Factors
Calcineurin Inhibitors
Population
Urology
Blood Pressure
Tacrolimus
Bone Density
Internal medicine
medicine
Humans
Aspartate Aminotransferases
education
Femoral neck
Bone mineral
Transplantation
education.field_of_study
business.industry
Bilirubin
Alkaline Phosphatase
medicine.disease
Ciclosporin
Liver Transplantation
Osteopenia
Calcineurin
Cholesterol
surgical procedures, operative
medicine.anatomical_structure
Endocrinology
Creatinine
Cyclosporine
Surgery
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 00411345
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Transplantation Proceedings
- Accession number :
- edsair.doi.dedup.....250998cd871e1e5dd1121537ec8b66a7