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Estimating the disease burden of methicillin-resistant Staphylococcus aureus in Japan: Retrospective database study of Japanese hospitals
- Source :
- PLoS ONE, PLoS ONE, Vol 12, Iss 6, p e0179767 (2017)
- Publication Year :
- 2017
-
Abstract
- Objectives The nationwide impact of antimicrobial-resistant infections on healthcare facilities throughout Japan has yet to be examined. This study aimed to estimate the disease burden of methicillin-resistant Staphylococcus aureus (MRSA) infections in Japanese hospitals. Design Retrospective analysis of inpatients comparing outcomes between subjects with and without MRSA infection. Data source A nationwide administrative claims database. Setting 1133 acute care hospitals throughout Japan. Participants All surgical and non-surgical inpatients who were discharged between April 1, 2014 and March 31, 2015. Main outcome measures Disease burden was assessed using hospitalization costs, length of stay, and in-hospital mortality. Using a unique method of infection identification, we categorized patients into an anti-MRSA drug group and a control group based on anti-MRSA drug utilization. To estimate the burden of MRSA infections, we calculated the differences in outcome measures between these two groups. The estimates were extrapolated to all 1584 acute care hospitals in Japan that have adopted a prospective payment system. Results We categorized 93 838 patients into the anti-MRSA drug group and 2 181 827 patients into the control group. The mean hospitalization costs, length of stay, and in-hospital mortality of the anti-MRSA drug group were US$33 548, 75.7 days, and 22.9%, respectively; these values were 3.43, 2.95, and 3.66 times that of the control group, respectively. When extrapolated to the 1584 hospitals, the total incremental burden of MRSA was estimated to be US$2 billion (3.41% of total hospitalization costs), 4.34 million days (3.02% of total length of stay), and 14.3 thousand deaths (3.62% of total mortality). Conclusions This study quantified the approximate disease burden of MRSA infections in Japan. These findings can inform policymakers on the burden of antimicrobial-resistant infections and support the application of infection prevention programs.
- Subjects :
- 0301 basic medicine
Male
Pediatrics
Databases, Factual
Nosocomial Infections
Staphylococcus
lcsh:Medicine
medicine.disease_cause
Geographical Locations
0302 clinical medicine
Cost of Illness
Japan
Acute care
Health care
Infection control
Public and Occupational Health
030212 general & internal medicine
Hospital Mortality
Hospital Costs
lcsh:Science
Pathology and laboratory medicine
Aged, 80 and over
Multidisciplinary
Pharmaceutics
Middle Aged
Staphylococcal Infections
Medical microbiology
Hospitalization
Infectious Diseases
Female
Pathogens
Research Article
Drug Utilization
Adult
Methicillin-Resistant Staphylococcus aureus
medicine.medical_specialty
Staphylococcus aureus
Drug Administration
Asia
Patients
Infectious Disease Control
030106 microbiology
Surgical and Invasive Medical Procedures
Microbiology
03 medical and health sciences
Drug Therapy
medicine
Humans
Disease burden
Aged
Retrospective Studies
Medicine and health sciences
Inpatients
Biology and life sciences
Bacteria
business.industry
lcsh:R
Organisms
Retrospective cohort study
Length of Stay
Methicillin-resistant Staphylococcus aureus
Microbial pathogens
Health Care
Emergency medicine
People and Places
lcsh:Q
Bacterial pathogens
Prospective payment system
business
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....25093777eceb78d13aad2c28fa933226