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CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma
- Source :
- Cancer Gene Therapy. 27:669-679
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Glioma is the most common tumor in the central nervous system that portends a poor prognosis. Key genes negatively related to survival may provide targets for therapy to improve the outcome of glioma. Here, we report a protein-coding gene CLEC5A, which is the top 1 gene by univariate Cox regression analysis of 524 primary GBM samples. Expression of CLEC5A is significantly correlated with decreased overall survival in patients with glioma via large-scale analysis. An analysis of 2589 patient samples showed that CLEC5A expression is higher in (1) glioblastoma than in lower-grade glioma and nontumor tissue, (2) in the mesenchymal subtype than in other subtypes, and (3) in IDH1-wild type glioblastoma than in IDH1-mutated glioblastoma. Notably, this tumor-associated biomarker is expressed preferentially on myeloid cells over glioma cells. And it shows a strong co-expression with M2 macrophage biomarker. Furthermore, CLEC5A-associated genes are enriched in immunosuppressive biological processes. The silico flow cytometry also showed CLEC5A expression related to less tumor purity and more tumor-promoting leukocytes infiltration. In conclusion, we proposed a new M2 biomarker expressed on myeloid cells that may decrease survival in patients with glioma through immunosuppressive mechanisms.
- Subjects :
- Male
0301 basic medicine
Cancer Research
medicine.medical_treatment
Central nervous system
Receptors, Cell Surface
Flow cytometry
03 medical and health sciences
0302 clinical medicine
Glioma
Biomarkers, Tumor
medicine
Humans
Lectins, C-Type
Myeloid Cells
neoplasms
Molecular Biology
Gene
Immunosuppression Therapy
medicine.diagnostic_test
business.industry
Mesenchymal stem cell
CLEC5A
Immunosuppression
Prognosis
M2 Macrophage
medicine.disease
Survival Analysis
nervous system diseases
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
Female
business
Subjects
Details
- ISSN :
- 14765500 and 09291903
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Cancer Gene Therapy
- Accession number :
- edsair.doi.dedup.....250726404ea17fdeb7ebcce0e70697d1