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Understanding the hematopoietic microenvironment in chronic myeloid leukemia: A concise review
- Source :
- Current Research in Translational Medicine. 69:103295
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Chronic myeloid leukemia (CML) is a myeloproliferative disease that results from the BCR-ABL gene-induced transformation of a primitive hematopoietic cell. This disease has been extensively studied, and, as a result, a very effective therapy has been developed: the tyrosine kinase inhibitors. Although, there is a significant knowledge about the intrinsic biology of CML cells, alterations in their bone marrow microenvironment are not yet completely understood. In this concise review, we summarized recent findings on the composition and function of the bone marrow microenvironment in CML, and their importance in the progression of the disease and treatment resistance.
- Subjects :
- 0301 basic medicine
Fusion Proteins, bcr-abl
Myeloproliferative disease
Disease
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Bone Marrow
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
hemic and lymphatic diseases
Tumor Microenvironment
medicine
Humans
neoplasms
Hematopoietic cell
business.industry
Myeloid leukemia
General Medicine
Hematopoietic Stem Cells
medicine.disease
Haematopoiesis
Leukemia
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cancer research
Bone marrow
business
Tyrosine kinase
Subjects
Details
- ISSN :
- 24523186
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Current Research in Translational Medicine
- Accession number :
- edsair.doi.dedup.....2502e52f4fbbf72856f3f17959be1ed9