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A META-ANALYSIS OF ABNORMAL GLUCOSE METABOLISM IN FIRST-EPISODE DRUG-NAIVE SCHIZOPHRENIA
- Source :
- Psychiatria Danubina, Volume 32, Issue 1
- Publication Year :
- 2020
- Publisher :
- Medicinska naklada, 2020.
-
Abstract
- Background: Patients with schizophrenia exhibit a higher mortality rate compared with the general population. This mortality has been attributed predominantly by the high risk of type 2 diabetes mellitus in the patients. We aimed to assess the inherent risk of glucose metabolism abnormalities in first-episode drug-naïve schizophrenia. Subjects and methods: We searched English database (PubMed, EMBASE, MEDLINE, Cochrane Library databases) and Chinese database (Wan Fang Data, CBM disc, VIP, and CNKI) from their inception until Jul 2018 for case-control studies examining glucose metabolism abnormalities. Measurements, such as fasting plasma glucose levels, fasting plasma insulin levels, insulin resistance and HbA1c levels in first episode antipsychotic-naive patients were used to test for prediabetes. Standardized/weighted mean differences and 95% confidence intervals were calculated and analyzed. Results: 19 studies (13 in English and 6 in Chinese) consisting of 1065 patients and 873 controls were included. Fasting plasma glucose levels (95% CI; 0.02 to 0.29; P=0.03), 2 h plasma glucose levels after an OGTT (95% CI; 0.63 to 1.2; P
- Subjects :
- Blood Glucose
medicine.medical_specialty
Population
Carbohydrate metabolism
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Internal medicine
Diabetes mellitus
medicine
Humans
Insulin
Prediabetes
education
First episode
education.field_of_study
business.industry
Type 2 Diabetes Mellitus
General Medicine
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Drug-naïve
Glucose
Diabetes Mellitus, Type 2
First-episode schizophrenia
drug-naïve
glucose metabolism
Schizophrenia
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 03535053
- Volume :
- 32
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Psychiatria Danubina
- Accession number :
- edsair.doi.dedup.....2502bfec636ae4f8500959102487c2c9