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Cycling in the nucleus: regulation of RNA 3′ processing and nuclear organization of replication-dependent histone genes
- Source :
- Romeo, Valentina; Schümperli, Daniel (2016). Cycling in the nucleus: regulation of RNA 3' processing and nuclear organization of replication-dependent histone genes. Current opinion in cell biology, 40, pp. 23-31. Elsevier 10.1016/j.ceb.2016.01.015
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The histones which pack new DNA during the S phase of animal cells are made from mRNAs that are cleaved at their 3' end but not polyadenylated. Some of the factors used in this reaction are unique to it while others are shared with the polyadenylation process that generates all other mRNAs. Recent work has begun to shed light on how the cell manages the assignment of these common components to the two 3' processing systems, and how it achieves their cell cycle-regulation and recruitment to the histone pre-mRNA. Moreover, recent and older findings reveal multiple connections between the nuclear organization of histone genes, their transcription and 3' end processing as well as the control of cell proliferation.
- Subjects :
- 0301 basic medicine
DNA Replication
Polyadenylation
Gene Expression
Histones
03 medical and health sciences
0302 clinical medicine
Transcription (biology)
Histone methylation
Histone H2A
medicine
RNA Precursors
Histone code
Animals
Humans
RNA, Messenger
RNA Processing, Post-Transcriptional
Genetics
Cell Nucleus
biology
Cell Cycle
DNA replication
Cell Cycle Checkpoints
Cell Biology
Cell biology
Cell nucleus
030104 developmental biology
medicine.anatomical_structure
Histone
030220 oncology & carcinogenesis
biology.protein
570 Life sciences
Subjects
Details
- ISSN :
- 09550674
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Cell Biology
- Accession number :
- edsair.doi.dedup.....24f8d43267b82a68798beed1fbc66d83
- Full Text :
- https://doi.org/10.1016/j.ceb.2016.01.015