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Striatal Dopamine Links Gastrointestinal Rerouting to Altered Sweet Appetite
- Source :
- Cell Metabolism
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Reductions in calorie intake contribute significantly to the positive outcome of bariatric surgeries. However, the physiological mechanisms linking the rerouting of the gastrointestinal tract to reductions in sugar cravings remain uncertain. We show that a duodenal-jejunal bypass (DJB) intervention inhibits maladaptive sweet appetite by acting on dopamine-responsive striatal circuitries. DJB disrupted the ability of recurrent sugar exposure to promote sweet appetite in sated animals, thereby revealing a link between recurrent duodenal sugar influx and maladaptive sweet intake. Unlike ingestion of a low-calorie sweetener, ingestion of sugar was associated with significant dopamine effluxes in the dorsal striatum, with glucose infusions into the duodenum inducing greater striatal dopamine release than equivalent jejunal infusions. Consistently, optogenetic activation of dopamine-excitable cells of the dorsal striatum was sufficient to restore maladaptive sweet appetite in sated DJB mice. Our findings point to a causal link between striatal dopamine signaling and the outcomes of bariatric interventions.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Physiology
media_common.quotation_subject
Striatum
Biology
Carbohydrate metabolism
Jejunum
03 medical and health sciences
0302 clinical medicine
Dopamine
Internal medicine
medicine
Ingestion
Molecular Biology
media_common
Gastrointestinal tract
digestive, oral, and skin physiology
Appetite
Cell Biology
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Duodenum
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 15504131
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Cell Metabolism
- Accession number :
- edsair.doi.dedup.....24f4e2b5dd987168dd27de28c1c52969