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POP-Brazil study protocol: a nationwide cross-sectional evaluation of the prevalence and genotype distribution of human papillomavirus (HPV) in Brazil
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, BMJ Open
- Publication Year :
- 2018
-
Abstract
- Introduction Human papillomavirus (HPV) is associated with the development of genital warts and different types of cancer, including virtually all cervical cancers and a considerable number of penile, anal and oropharyngeal cancers. Data regarding the prevalence of HPV infection in Brazil are limited and fragmented. We aim to determine HPV prevalence in sexually active women and men aged 16–25 years and to investigate regional differences in virus prevalence and types. Methods and analysis This is a nationwide, multicentric, cross-sectional, prospective study that will include participants aged 16–25 years from all Brazilian capital cities. Recruitment will occur in primary health units by trained health professionals who will be responsible for collecting biological samples and interviewing the volunteers. After signing informed consent, all participants will answer a questionnaire that will collect sociodemographic and behavioural data. All samples will be processed in a certified central laboratory, and strict quality control will be performed by many different procedures, including double data entry, training and certification of primary care health professionals responsible for data collection, simulation of interviews, and auditing and monitoring of visits. The sample size will be standardised based on the population distribution of each capital using SAS and R statistical software. Ethics and dissemination The project was approved by the research ethics committee of the main institution and the corresponding ethics committees of the recruitment sites. This will be the first Brazilian nationwide study to determine overall HPV prevalence and to examine regional differences and social, demographic and behavioural factors related to HPV infection. Critical analysis of the study results will contribute to epidemiological knowledge and will set a baseline for future evaluation of the impact of the National HPV Vaccination Program.
- Subjects :
- Male
Health Knowledge, Attitudes, Practice
Epidemiology
Genital warts
0302 clinical medicine
Informed consent
Protocol
Medicine
Mass Screening
Multicenter Studies as Topic
nationwide study
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Papillomaviridae
education.field_of_study
hpv infection
Vaccination
HPV infection
General Medicine
Research Design
030220 oncology & carcinogenesis
Regression Analysis
Female
Brazil
Adult
medicine.medical_specialty
Adolescent
Genotype
Population
prevalence
INFLAMAÇÃO
Specimen Handling
03 medical and health sciences
Young Adult
Humans
anogenital
education
Research ethics
Data collection
business.industry
Papillomavirus Infections
Reproducibility of Results
medicine.disease
Cross-Sectional Studies
Family medicine
DNA, Viral
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, BMJ Open
- Accession number :
- edsair.doi.dedup.....24f44c0bac5756579adc101d9213f9e4