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Cellular antioxidant activity and in vitro intestinal permeability of phenolic compounds from four varieties of mango bark (Mangifera indica L.)
- Source :
- Journal of the science of food and agriculture. 99(7)
- Publication Year :
- 2018
-
Abstract
- Mango bark is an important agro-industrial residue from mango pruning. In traditional medicine, the aqueous extract from mango bark (MBE) has been used in ethnomedicine for the treatment of many diseases. However, there is scarce information using cellular models to evaluate the potential use of this plant material for human consumption. In this study, the phenolic content from the MBE from four varieties (Kent, Keitt, Ataulfo and Tommy Atkins) was analyzed by high-performance liquid chromatography coupled to photodiode array detector (HPLC-DAD) and liquid chromatography coupled with time-of-flight mass spectrometry (LC/MS-TOF). Additionally, the cellular antioxidant activity of the MBE from the four mango varieties were compared. Finally, the intestinal permeability of the main polyphenols found in the MBE (mangiferin and gallic acid) was evaluated. RESULTS Mangiferin and gallic acid were the main constituents in the MBE from the four mango varieties. Furthermore, the Ataulfo variety showed the highest cellular antioxidant activity (67%) at the concentration of 100 µg mL?1. The intestinal permeability of mangiferin present in the bark extracts was 3- to 4.8-fold higher than those of mangiferin as standard, whereas the intestinal permeability of gallic acid varied among the tested extracts. CONCLUSION MBE has the potential to exert antioxidant activity at the cellular level and can have an impact on human health. It may also be a good source for the extraction of polyphenols mainly mangiferin. ? 2019 Society of Chemical Industry
- Subjects :
- Antioxidant
030309 nutrition & dietetics
medicine.medical_treatment
Xanthones
Cellular level
Antioxidants
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
Phenols
Gallic Acid
medicine
Humans
Mangifera
Food science
Gallic acid
Intestinal Mucosa
Mangiferin
0303 health sciences
Nutrition and Dietetics
Intestinal permeability
Plant Extracts
04 agricultural and veterinary sciences
medicine.disease
040401 food science
In vitro
chemistry
Polyphenol
Plant Bark
Caco-2 Cells
Agronomy and Crop Science
Food Science
Biotechnology
Subjects
Details
- ISSN :
- 10970010
- Volume :
- 99
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of the science of food and agriculture
- Accession number :
- edsair.doi.dedup.....24f068ffebd7f433bd0cd9679a892e6c