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The Relationship Between Serum Interleukin-1α and Asymptomatic Infrarenal Abdominal Aortic Aneurysm Size, Morphology, and Growth Rates
- Source :
- European Journal of Vascular and Endovascular Surgery. 56:130-135
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- OBJECTIVE/BACKGROUND In a pilot study, a relationship between abdominal aortic aneurysm (AAA) diameter and serum interleukin (IL)-1α levels was reported, and that endothelial cell (EC) activation in vitro in response to serum from patients with AAA was blocked by anti-IL-1α antibodies. The aim of the present study was to further investigate the relationship between serum IL-1α and asymptomatic infrarenal AAA size, morphology, and growth rates. METHODS Serum IL-1α was measured using enzyme linked immunosorbent assay in 101 patients with asymptomatic, infrarenal AAA and related to aneurysm size, morphology, and growth rates. RESULTS IL-1α was measured in 101 patients. There was no statistically significant difference in mean age between men and women. IL-1α was detectable in 62.4% of patients; median IL-1α titre was 3.26 pg/mL. There was no statistically significant relationship between IL-1α and maximum AAA antero-posterior diameter as measured by ultrasound (p = .649), AAA morphology (aortic length [p = .394], sac [p = .369], and thrombus volume [p = .629]) as measured on computed tomography, absolute increase in AAA diameter (p = .214), or AAA growth rate (p = .230). CONCLUSION IL-1α is detectable in the majority of patients with infrarenal AAA, but the cause and clinical significance of this novel observation remains unknown.
- Subjects :
- Male
medicine.medical_specialty
Aortography
Computed Tomography Angiography
macromolecular substances
030204 cardiovascular system & hematology
Asymptomatic
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Aneurysm
Interleukin-1alpha
Internal medicine
medicine
Humans
Clinical significance
Aorta, Abdominal
cardiovascular diseases
Thrombus
Aged
Ultrasonography
Computed tomography angiography
Aged, 80 and over
medicine.diagnostic_test
business.industry
Interleukin
medicine.disease
Abdominal aortic aneurysm
Asymptomatic Diseases
Disease Progression
cardiovascular system
Female
Surgery
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Biomarkers
030217 neurology & neurosurgery
Aortic Aneurysm, Abdominal
Dilatation, Pathologic
Subjects
Details
- ISSN :
- 10785884
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- European Journal of Vascular and Endovascular Surgery
- Accession number :
- edsair.doi.dedup.....24e291ccb727a531eda10baba494fa52