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Prevalence of resistance mutations related to integrase inhibitor S/GSK1349572 in HIV-1 subtype B raltegravir-naive and -treated patients
- Source :
- Journal of Antimicrobial Chemotherapy; Vol 66
- Publication Year :
- 2011
- Publisher :
- Oxford University Press (OUP), 2011.
-
Abstract
- Objectives To compare the frequency of previously in vitro-selected integrase mutations (T124A, T124A/S153F, S153Y, T124A/S153Y and L101I/T124A/S153Y) conferring resistance to S/GSK1349572 between HIV-1 subtype B integrase inhibitor (INI)-naive and raltegravir-treated patients. Methods Integrase sequences from 650 INI-naive patients and 84 raltegravir-treated patients were analysed. Results The T124A mutation alone and the combination T124A/L101I were more frequent in raltegravir-failing patients than in INI-naive patients (39.3% versus 24.5%, respectively, P = 0.005 for T124A and 20.2% versus 10.0%, respectively, P = 0.008 for T124A/L101I). The S153Y/F mutations were not detected in any integrase sequence (except for S153F alone, only detected in one INI-naive patient). Conclusions T124A and T124A/L101I, more frequent in raltegravir-treated patients, could have some effect on raltegravir response and their presence could play a role in the selection of other mutations conferring S/GSK1349572 resistance. The impact of raltegravir-mediated changes such as these on the virological response to S/GSK1349572 should be studied further.
- Subjects :
- Microbiology (medical)
Genotype
Anti-HIV Agents
Pyridones
Mutation, Missense
Integrase inhibitor
HIV Infections
HIV Integrase
Drug resistance
Piperazines
Raltegravir Potassium
Viral Proteins
03 medical and health sciences
0302 clinical medicine
Drug Resistance, Viral
Oxazines
Prevalence
medicine
Humans
Missense mutation
Pharmacology (medical)
030212 general & internal medicine
Anthracenes
Pharmacology
0303 health sciences
biology
030306 microbiology
Sequence Analysis, DNA
Settore MED/07 - Microbiologia e Microbiologia Clinica
Raltegravir
biology.organism_classification
Virology
Pyrrolidinones
3. Good health
Integrase
Infectious Diseases
Amino Acid Substitution
Immunology
Lentivirus
HIV-1
biology.protein
Heterocyclic Compounds, 3-Ring
medicine.drug
Subjects
Details
- ISSN :
- 14602091 and 03057453
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Journal of Antimicrobial Chemotherapy
- Accession number :
- edsair.doi.dedup.....24df7c661805d28f065b33d6dda8af62