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Immunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trial monoclonal antibodies
- Source :
- Drug Design, Development and Therapy
- Publication Year :
- 2017
- Publisher :
- Dove Medical Press, 2017.
-
Abstract
- Colorectal cancer is considered a disease of the elderly population. Since the number of geriatric patients continues to rise, monoclonal antibody therapy is the most promising therapy in the recent research. Presently, the monoclonal antibodies most frequently used in the treatment of colorectal tumors are bevacizumab, cetuximab, panitumumab, and ramucirumab. Bevacizumab is a monoclonal antibody that acts on VEGF. Cetuximab and panitumumab act on EGFR. Ramucirumab binds directly to the ligand-binding pocket of VEGFR-2 to block the binding of VEGF-A, VEGF-C, and VEGF-D. These monoclonal antibodies, alone or in association with radiotherapy or chemotherapy, are presenting good results and are increasing patient survival, despite the side effects. Due to the limited number of molecules available, several studies are trying to develop new monoclonal antibodies for the treatment of colorectal tumors. Among those being studied, some recent molecules are in phase I and/or II trials and are yielding advantageous results, such as anti-DR5, anti-Fn14, anti-IGF-1R, anti-EGFR, anti-NRP1, and anti-A33 antibodies. This has been successful in reducing side effects and in treating nonresponsive patients.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Bevacizumab
medicine.drug_class
Colorectal cancer
ramucirumab
medicine.medical_treatment
Pharmaceutical Science
Review
bevacizumab
Monoclonal antibody
Ramucirumab
03 medical and health sciences
0302 clinical medicine
Internal medicine
Drug Discovery
cetuximab
medicine
Panitumumab
Humans
Monoclonal antibody therapy
Pharmacology
Cetuximab
business.industry
Antibodies, Monoclonal
medicine.disease
Radiation therapy
ErbB Receptors
030104 developmental biology
030220 oncology & carcinogenesis
Immunology
monoclonal antibodies
Immunotherapy
business
panitumumab
Colorectal Neoplasms
medicine.drug
colorectal tumor
Subjects
Details
- Language :
- English
- ISSN :
- 11778881
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Drug Design, Development and Therapy
- Accession number :
- edsair.doi.dedup.....24d9662eff300a2ae11257cd05faad91