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Comparative mammary gland postnatal development and tumourigenesis in the sheep, cow, cat and rabbit: Exploring the menagerie
- Source :
- Seminars in Cell & Developmental Biology. 114:186-195
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Sheep, cows, cats, and rabbits are kept by humans for agricultural purposes and as companion animals. Much of the mammary research in these species has focussed on mastitis in the case of ruminants and rabbits, and mammary tumourigenesis in cats and rabbits. However, similarities with the human breast suggest that these species may be currently underutilised as valuable comparative models of breast development and disease. The mammary gland undergoes cyclical postnatal development that will be considered here in the context of these non-traditional model species, with a focus on the mammary microenvironment at different postnatal developmental stages. The second part of this review will consider mammary tumour development. Ruminants are thought to be relatively 'resistant' to mammary tumourigenesis, likely due to multiple factors including functional properties of ruminant mammary stem/progenitor cells, diet, and/or the fact that production animals undergo a first parity soon after puberty. By contrast, unneutered female cats and rabbits have a propensity to develop mammary neoplasms, and subsets of these may constitute valuable comparative models of breast cancer.
- Subjects :
- Postnatal Care
0301 basic medicine
Carcinogenesis
Mammary gland
Physiology
Context (language use)
Rabbit
Disease
Biology
03 medical and health sciences
Mammary Glands, Animal
0302 clinical medicine
Breast cancer
medicine
Animals
Progenitor cell
Breast development
Sheep
CATS
Cow
Cat
Cell Biology
medicine.disease
Mastitis
030104 developmental biology
medicine.anatomical_structure
Cats
Cattle
Female
Rabbits
Tumour
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 10849521
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- Seminars in Cell & Developmental Biology
- Accession number :
- edsair.doi.dedup.....24d7b7f05e35f8343d9ee5664009ca4f