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Expression of adhesion molecules in endothelial cells during allogeneic bone marrow transplantation
- Source :
- European journal of haematology. 52(5)
- Publication Year :
- 1994
-
Abstract
- Endothelial cell activation during allogeneic bone marrow transplantation, mainly in acute graft-versus-host disease (aGvHD) was studied in 23 recipients and 5 controls using anti-von Willebrand factor (vWF) antibody, antibodies to endothelial leukocyte adhesion molecule-1 (ELAM-1), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), and anti-HLA-DQ antibody, by immunohistological staining of skin. vWF extravasation, ELAM-1 and VCAM-1 expression were present in most recipients with a cutaneous rash which was confirmed as an aGvHD by histological examination (documented aGvHD) (p = 0.005 for vWF extravasation and ELAM-1 expression and p = 0.03 for VCAM-1 expression in comparison with the controls). In recipients with a rash, the cases displaying vWF extravasation and ELAM-1 expression were significantly more numerous in those with a documented aGvHD than in those without histological features of aGvHD (p = 0.01). vWF extravasation and ELAM-1 occurred concomitantly (p
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Graft vs Host Disease
Vascular Cell Adhesion Molecule-1
Inflammation
Skin Diseases
hemic and lymphatic diseases
Immunopathology
HLA-DQ Antigens
von Willebrand Factor
medicine
Humans
Endothelium
Cell adhesion
Bone Marrow Transplantation
integumentary system
biology
Cell adhesion molecule
business.industry
Hematology
General Medicine
Middle Aged
Intercellular Adhesion Molecule-1
Extravasation
Endothelial stem cell
medicine.anatomical_structure
Immunology
Acute Disease
cardiovascular system
biology.protein
Female
Bone marrow
medicine.symptom
Antibody
business
E-Selectin
Cell Adhesion Molecules
Subjects
Details
- ISSN :
- 09024441
- Volume :
- 52
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- European journal of haematology
- Accession number :
- edsair.doi.dedup.....24d1c8f8ae2ea4fa50d5c01958f351a0