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Statin use and the risk of Clostridium difficile in academic medical centres
- Source :
- Gut. 61(11)
- Publication Year :
- 2012
-
Abstract
- Objectives To estimate the possible relationship between statin use and the risk of healthcare facility onset Clostridium difficile . Methods Patients over 18 years of age admitted to hospitals contributing data to the University HealthSystem Consortium between 2002 and 2009 were eligible. Patients with the ICD-9-CM code 008.45 who received a minimum 3-day course of either metronidazole or oral vancomycin on/after day 5 of admission were considered incident cases of C difficile infection. 31 472 incident cases of C difficile infection were identified and matched to five controls, on hospital, year/quarter of admission date, and age ±10 years (N=78 096). Patients who were administered one drug in the statin class (atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin or simvastatin) before the index date were considered to be exposed. Conditional logistic regression modelling provided adjusted odds ratios and 95% CI. Results Compared with non-users, users of any drug within the statin class were 0.78 times less likely to develop C difficile infection in the hospital (95% CI 0.75 to 0.81) adjusting for potential confounders. Differences in estimates for specific statins were minimal. Niacin, fibrates and selective cholesterol absorption inhibitors showed no association with the risk of C difficile infection. Conclusions Our data were consistent with a growing body of literature demonstrating a reduced risk of infections with statin use. Statins9 pleiotropic properties may provide protection against C difficile infection.
- Subjects :
- Male
Simvastatin
Databases, Factual
Reference Values
Atorvastatin
Odds Ratio
Aged, 80 and over
Academic Medical Centers
Cross Infection
Incidence
Gastroenterology
Clostridium difficile
clostridium difficile
Middle Aged
Female
Risk assessment
medicine.drug
Adult
medicine.medical_specialty
Statin
medicine.drug_class
Risk Assessment
statins
Young Adult
Age Distribution
Internal medicine
medicine
Confidence Intervals
Humans
Rosuvastatin
Pyrroles
Sex Distribution
Aged
business.industry
Clostridioides difficile
Settore MED/09 - MEDICINA INTERNA
nutritional and metabolic diseases
Odds ratio
United States
Surgery
Metronidazole
Logistic Models
Heptanoic Acids
Case-Control Studies
Clostridium Infections
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Pravastatin
Fluvastatin
Follow-Up Studies
Subjects
Details
- ISSN :
- 14683288
- Volume :
- 61
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Gut
- Accession number :
- edsair.doi.dedup.....24ca766942f8f836af05e934a837ce1d