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Novel renal markers for the assessment of renal integrity in patients undergoing knee arthroplasty – a pilot study
- Source :
- Journal of Experimental Orthopaedics, Vol 5, Iss 1, Pp 1-8 (2018), Journal of Experimental Orthopaedics
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Background The feasibility of novel kidney injury biomarkers in consecutive patients having total knee arthroplasty with local infiltration analgesia was evaluated. Methods We enrolled 30 patients scheduled for elective unilateral total knee arthroplasty. Paired plasma and urine samples were taken before surgery and at 4 h, 24 h and 48 h after surgery to measure creatinine, cystatin C, neutrophil gelatinase associated lipocalin, kidney injury molecule-1, interleukin-18 and liver-type fatty acid-binding protein. Results At baseline, 13 subjects had normal kidney function, 15 had mild and two had moderate kidney failure evaluated by calculated glomerular filtration rate. None of the subjects had all measured novel renal markers below proposed cut-off concentrations. Altogether 28/30 subjects had one (n = 3), two (n = 7) or three (n = 18) plasma neutrophil gelatinase associated lipocalin values above normal. In seven of these 28 subjects plasma creatinine, calculated glomerular filtration rate and plasma cystatin C were within the reference values. Five subjects had a low urine output
- Subjects :
- medicine.medical_specialty
Arthroplasty, replacement, knee
medicine.medical_treatment
030232 urology & nephrology
Urology
Renal function
Urine
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
lcsh:Orthopedic surgery
Medicine
Orthopedics and Sports Medicine
Cystatin C
Creatinine
Kidney
biology
business.industry
Research
Acute kidney injury
Anti-inflammatory agents, non-steroidal
medicine.disease
Arthroplasty
Kidney injury molecule-1 protein
lcsh:RD701-811
medicine.anatomical_structure
chemistry
Neutrophil gelatinase associated lipocalin
biology.protein
Cystatin
Glomerular filtration rate
business
Subjects
Details
- ISSN :
- 21971153
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Orthopaedics
- Accession number :
- edsair.doi.dedup.....24bdd8d674a82d47df6cd3994783e0cc