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Frontal-executive and corticolimbic structural brain circuitry in older people with remitted depression, mild cognitive impairment, Alzheimer’s dementia, and normal cognition
- Source :
- Neuropsychopharmacology
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- A history of depression is a risk factor for dementia. Despite strong epidemiologic evidence, the pathways linking depression and dementia remain unclear. We assessed structural brain alterations in white and gray matter of frontal-executive and corticolimbic circuitries in five groups of older adults putatively at-risk for developing dementia- remitted depression (MDD), non-amnestic MCI (naMCI), MDD+naMCI, amnestic MCI (aMCI), and MDD+aMCI. We also examined two other groups: non-psychiatric (“healthy”) controls (HC) and individuals with Alzheimer’s dementia (AD). Magnetic resonance imaging (MRI) data were acquired on the same 3T scanner. Following quality control in these seven groups, from diffusion-weighted imaging (n = 300), we compared white matter fractional anisotropy (FA), mean diffusivity (MD), and from T1-weighted imaging (n = 333), subcortical volumes and cortical thickness in frontal-executive and corticolimbic regions of interest (ROIs). We also used exploratory graph theory analysis to compare topological properties of structural covariance networks and hub regions. We found main effects for diagnostic group in FA, MD, subcortical volume, and cortical thickness. These differences were largely due to greater deficits in the AD group and to a lesser extent aMCI compared with other groups. Graph theory analysis revealed differences in several global measures among several groups. Older individuals with remitted MDD and naMCI did not have the same white or gray matter changes in the frontal-executive and corticolimbic circuitries as those with aMCI or AD, suggesting distinct neural mechanisms in these disorders. Structural covariance global metrics suggested a potential difference in brain reserve among groups.
- Subjects :
- medicine.medical_specialty
Neuropsychological Tests
Audiology
behavioral disciplines and activities
Article
White matter
03 medical and health sciences
Cognition
0302 clinical medicine
Alzheimer Disease
mental disorders
Fractional anisotropy
medicine
History of depression
Humans
Dementia
Cognitive Dysfunction
Aged
Cognitive reserve
Pharmacology
medicine.diagnostic_test
Depression
business.industry
Brain
Magnetic resonance imaging
medicine.disease
030227 psychiatry
Psychiatry and Mental health
medicine.anatomical_structure
Older people
business
030217 neurology & neurosurgery
Brain circuitry
Subjects
Details
- ISSN :
- 1740634X and 0893133X
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....24bd94adc06be3a236f18940483de658