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Double-Targeting Explosible Nanofirework for Tumor Ignition to Guide Tumor-Depth Photothermal Therapy
- Source :
- Small. 14:1800292
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- This study reports a double-targeting "nanofirework" for tumor-ignited imaging to guide effective tumor-depth photothermal therapy (PTT). Typically, ≈30 nm upconversion nanoparticles (UCNP) are enveloped with a hybrid corona composed of ≈4 nm CuS tethered hyaluronic acid (CuS-HA). The HA corona provides active tumor-targeted functionality together with excellent stability and improved biocompatibility. The dimension of UCNP@CuS-HA is specifically set within the optimal size window for passive tumor-targeting effect, demonstrating significant contributions to both the in vivo prolonged circulation duration and the enhanced size-dependent tumor accumulation compared with ultrasmall CuS nanoparticles. The tumors featuring hyaluronidase (HAase) overexpression could induce the escape of CuS away from UCNP@CuS-HA due to HAase-catalyzed HA degradation, in turn activating the recovery of initially CuS-quenched luminescence of UCNP and also driving the tumor-depth infiltration of ultrasmall CuS for effective PTT. This in vivo transition has proven to be highly dependent on tumor occurrence like a tumor-ignited explosible firework. Together with the double-targeting functionality, the pathology-selective tumor ignition permits precise tumor detection and imaging-guided spatiotemporal control over PTT operation, leading to complete tumor ablation under near infrared (NIR) irradiation. This study offers a new paradigm of utilizing pathological characteristics to design nanotheranostics for precise detection and personalized therapy of tumors.
- Subjects :
- Luminescence
Materials science
Biocompatibility
Nanofibers
Hyaluronoglucosaminidase
Mice, Nude
Nanoparticle
02 engineering and technology
Sulfides
010402 general chemistry
01 natural sciences
Tumor ablation
law.invention
Biomaterials
Mice
In vivo
law
Neoplasms
Spheroids, Cellular
Animals
Humans
General Materials Science
Hyaluronic Acid
Personalized therapy
Mice, Inbred BALB C
Cell Death
Temperature
Hep G2 Cells
Hyperthermia, Induced
General Chemistry
Phototherapy
Photothermal therapy
021001 nanoscience & nanotechnology
0104 chemical sciences
Ignition system
Tumor detection
RAW 264.7 Cells
NIH 3T3 Cells
Nanoparticles
0210 nano-technology
Copper
Biotechnology
Biomedical engineering
Subjects
Details
- ISSN :
- 16136810
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Small
- Accession number :
- edsair.doi.dedup.....24b999025f6a4e7f82ed31c328f5cbb9