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Implications of PEGylation of Carbon Nanotubes for Central Nervous System Bioavailability
- Source :
- CNS & Neurological Disorders - Drug Targets. 16
- Publication Year :
- 2018
- Publisher :
- Bentham Science Publishers Ltd., 2018.
-
Abstract
- BACKGROUND AND OBJECTIVE In this mini-review, we have compiled the most recent and comparable information to shed light on the action of PEGylation in the biodistribution of carbon nanotubes (CNT) in the central nervous system (CNS). It is well known that due to the complexity of the CNS and the severity of the outcome following changes in this system, this is one of the areas where there are more investments in research to develop new technologies and approaches for more effective and less invasive treatments. The CNS is highly protected against toxic and invasive microorganisms thanks to the blood brain barrier (BBB), but this protection also prevents the passage of potentially beneficial molecules for the treatment of neurological disorders. Nanotechnology attempts to develop nanocompounds that are biocompatible and non-immunogenic, and that are able to cross the BBB in therapeutic amounts without causing damage and to diffuse through nerve tissue. These compounds should also be cleared and biodistributed properly, being capable of performing drug delivery exclusively for CNS pathologies, such as neurodegenerative diseases (Parkinson's and Alzheimer's) and brain tumors. CONCLUSION In this way, this review focuses on CNT PEGylation, aiming to help in the development of viable and effective nanomedicines for neuroscience applications.
- Subjects :
- Biodistribution
Central nervous system
02 engineering and technology
Blood–brain barrier
Polyethylene Glycols
03 medical and health sciences
0302 clinical medicine
Central Nervous System Diseases
medicine
Animals
Humans
Nanotechnology
Tissue Distribution
Pharmacology
Nanotubes, Carbon
business.industry
General Neuroscience
021001 nanoscience & nanotechnology
Biocompatible material
Bioavailability
medicine.anatomical_structure
Blood-Brain Barrier
Drug delivery
PEGylation
0210 nano-technology
business
Neuroscience
030217 neurology & neurosurgery
Clearance
Subjects
Details
- ISSN :
- 18715273
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- CNS & Neurological Disorders - Drug Targets
- Accession number :
- edsair.doi.dedup.....24b48d1f6b3e2a5748dbf1ab51eb3c78