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Correlation and clinical relevance of animal models for inhaled pharmaceuticals and biopharmaceuticals
- Source :
- Advanced Drug Delivery Reviews, Advanced Drug Delivery Reviews, Elsevier, 2020, 167, pp.148-169. ⟨10.1016/j.addr.2020.06.029⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; Nonclinical studies are fundamental for the development of inhaled drugs, as for any drug product, and for successful translation to clinical practice. They include in silico, in vitro, ex vivo and in vivo studies and are intended to provide a comprehensive understanding of the inhaled drug beneficial and detrimental effects. To date, animal models cannot be circumvented during drug development programs, acting as surrogates of humans to predict inhaled drug response, fate and toxicity. Herein, we review the animal models used during the different development stages of inhaled pharmaceuticals and biopharmaceuticals, highlighting their strengths and limitations.
- Subjects :
- 2019-20 coronavirus outbreak
[SDV]Life Sciences [q-bio]
Drug Evaluation, Preclinical
Inhaled drug
Oropharynx
Pharmaceutical Science
Rodentia
02 engineering and technology
Bioinformatics
03 medical and health sciences
Pharmacokinetics
In vivo
Administration, Inhalation
toxicokinetics
pharmacodynamics
Animals
Humans
Medicine
Clinical significance
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Aerosols
Biological Products
Respiratory Distress Syndrome
0303 health sciences
inhalation
United States Food and Drug Administration
business.industry
021001 nanoscience & nanotechnology
United States
animal models
3. Good health
[SDV] Life Sciences [q-bio]
Clinical Practice
Pharmaceutical Preparations
Drug development
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Models, Animal
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Drug product
0210 nano-technology
business
pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0169409X and 18728294
- Database :
- OpenAIRE
- Journal :
- Advanced Drug Delivery Reviews, Advanced Drug Delivery Reviews, Elsevier, 2020, 167, pp.148-169. ⟨10.1016/j.addr.2020.06.029⟩
- Accession number :
- edsair.doi.dedup.....24afaac6cec1655a3db1a64f24075770