Back to Search
Start Over
Clinical and biological markers of premature aging after autologous SCT in childhood cancer
- Source :
- Bone marrow transplantation. 52(4)
- Publication Year :
- 2016
-
Abstract
- The aim of this study was to analyze the prevalence of frailty and physical health limitations among long-term survivors of high-risk neuroblastoma (HR NBL) and to investigate whether frail health is associated with variables of cardiovascular function, markers of inflammation and telomere length. A national study cohort of 19 (median age 22, range 16-30 years) long-term (>10 years) HR NBL survivors was studied and the findings were compared with 20 age- and sex-matched controls. Frailty was defined as ⩾3 of the following conditions: low muscle mass, low energy expenditure, slow running and weakness. The prevalence of frailty was significantly higher among the HR NBL survivors 9/19 (47%) than among the controls (0%). Thirteen (68%) of the survivors reported significant physical health limitations in vigorous activities, as opposed to none of the controls. The HR NBL survivors had significantly shorter telomere length and higher serum levels of high sensitivity C-reactive protein than did the controls. Frail health and poor physical functioning are prevalent among HR NBL survivors and suggest premature aging. Survivors with gonadal damage, very low fat mass percentage, low glycosylated hemoglobin A1c and increased common carotid artery intima-media thickness may be more prone to early aging after high dose therapy.
- Subjects :
- Premature aging
Adult
Male
medicine.medical_specialty
Weakness
Adolescent
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
Transplantation, Autologous
Cohort Studies
03 medical and health sciences
Neuroblastoma
Young Adult
0302 clinical medicine
Internal medicine
medicine
Prevalence
Humans
Survivors
Young adult
Transplantation
biology
Frailty
business.industry
C-reactive protein
Hematopoietic Stem Cell Transplantation
Aging, Premature
Hematology
Telomere
3. Good health
Surgery
Blood pressure
C-Reactive Protein
030220 oncology & carcinogenesis
Cohort
biology.protein
Female
medicine.symptom
business
Biomarkers
Cohort study
Subjects
Details
- ISSN :
- 14765365
- Volume :
- 52
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Bone marrow transplantation
- Accession number :
- edsair.doi.dedup.....2495eccec6f48e7f3cbe145207359004