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pUDK-HGF Gene Therapy to Relieve CLI Rest Pain and Ulcer: A Phase II, Double-Blind, Randomized Placebo-Controlled Trial
- Source :
- Human Gene Therapy. 32:839-849
- Publication Year :
- 2021
- Publisher :
- Mary Ann Liebert Inc, 2021.
-
Abstract
- This phase II clinical trial investigated the efficacy and safety of intramuscular injection of plasmid pUDK-HGF, which encodes the human hepatocyte growth factor gene in patients with critical limb ischemia. Resting pain patients (
- Subjects :
- Chronic Limb-Threatening Ischemia
medicine.medical_specialty
Genetic enhancement
Placebo-controlled study
Pain
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Ischemia
Internal medicine
Genetics
medicine
Humans
Molecular Biology
Ulcer
Rest (music)
030304 developmental biology
0303 health sciences
Hepatocyte Growth Factor
business.industry
Genetic Therapy
Critical limb ischemia
Clinical trial
030220 oncology & carcinogenesis
Molecular Medicine
Hepatocyte growth factor
medicine.symptom
business
Intramuscular injection
Growth Factor Gene
medicine.drug
Subjects
Details
- ISSN :
- 15577422 and 10430342
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Human Gene Therapy
- Accession number :
- edsair.doi.dedup.....2488fbaf3039fa96fab5bf4d0e970a35