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Physiological Society of Japan
- Source :
- The Journal of Physiological Sciences. 63:401-408
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- This study examined mechanical and thermal hypersensitivity in the rat hind paw during cast immobilization of the hind limbs for 4 or 8 weeks and following cast removal. Blood flow, skin temperature, and volume of the rat hind paw were assessed in order to determine peripheral circulation of the hind limbs. Sensitization was analyzed by measuring the expression of the calcitonin gene-related peptide (CGRP) in the spinal dorsal horn following cast immobilization. Two weeks post immobilization, mechanical and thermal sensitivities increased significantly in all rats; however, peripheral circulation was not affected by immobilization. Cast immobilization for 8 weeks induced more serious hypersensitivity compared to cast immobilization for 4 weeks. Moreover, CGRP expression in the deeper lamina layer of the spinal dorsal horn increased in the rats immobilized for 8 weeks but not in those immobilized for 4 weeks. These findings suggest that immobilization-induced hypersensitivity develops during the immobilization period without affecting peripheral circulation. Our results also highlight the possibility that prolonged immobilization induces central sensitization in the spinal cord.<br />The final publication is available at link.springer.com<br />The Journal of Physiological Sciences, 63(6), pp.401-408; 2013
- Subjects :
- medicine.medical_specialty
Central sensitization
Physiology
Calcitonin Gene-Related Peptide
Calcitonin gene-related peptide
Immobilization
Internal medicine
Hypersensitivity
medicine
Animals
Cast immobilization
CGRP
Sensitization
Spinal cord
Chemistry
Skin temperature
Hindlimb
Rats
Peripheral
Endocrinology
medicine.anatomical_structure
Hyperalgesia
Calcitonin
Anesthesia
Rat
Skin Temperature
Subjects
Details
- ISSN :
- 18806562 and 18806546
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- The Journal of Physiological Sciences
- Accession number :
- edsair.doi.dedup.....2488dcccbb8fa999f50cf05a1f0a55ba