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Necroptosis: (Last) Message in a Bubble
- Source :
- Immunity. 47:1-3
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- RIPK3 kinase-mediated phosphorylation of MLKL pseudokinase is the execution event of necroptosis. Two independent reports—in Immunity (Yoon et al., 2017) and Cell (Gong et al., 2017)—reveal that MLKL affects homeostatic membrane trafficking and necroptosis-enhanced bubble formation involving interaction with the ESCRT machinery.
- Subjects :
- 0301 basic medicine
Programmed cell death
ESCRT Machinery
Endosomal Sorting Complexes Required for Transport
Necroptosis
Cell Membrane
Immunology
Apoptosis
macromolecular substances
Biology
Cell biology
Extracellular Vesicles
Necrosis
Protein Transport
03 medical and health sciences
030104 developmental biology
Infectious Diseases
Receptor-Interacting Protein Serine-Threonine Kinases
Animals
Humans
Immunology and Allergy
Phosphorylation
Protein Kinases
Subjects
Details
- ISSN :
- 10747613
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....247ed293369f5eb57aac674e3883c8df