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Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 26:1233-1236
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- A series of pyridoxine hydroxamic acid analog bearing a 5-aryl-spacers were synthesized. Evaluation of these novel HIV integrase complex inhibitors revealed compounds with high potency against wild-type HIV virus.
- Subjects :
- 0301 basic medicine
030106 microbiology
Clinical Biochemistry
Pharmaceutical Science
HIV Integrase
Hydroxamic Acids
Virus Replication
Biochemistry
Virus
Rats, Sprague-Dawley
Inhibitory Concentration 50
Structure-Activity Relationship
03 medical and health sciences
chemistry.chemical_compound
Catalytic Domain
Drug Discovery
medicine
Animals
Humans
Potency
Structure–activity relationship
HIV Integrase Inhibitors
Molecular Biology
Hydroxamic acid
biology
Organic Chemistry
Pyridoxine
virus diseases
Virology
Rats
Integrase
030104 developmental biology
chemistry
Viral replication
HIV-1
biology.protein
Molecular Medicine
Female
Half-Life
medicine.drug
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....247df711c29abf29f445151da7695e14
- Full Text :
- https://doi.org/10.1016/j.bmcl.2016.01.028