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Gamma-aminobutyric acid (GABA) immunocytochemistry of laser coagulations in the rabbit retina
- Source :
- Experimental Eye Research. 52:59-63
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- Rabbit retinas were treated with laser coagulations of low intensity, using five different wavelengths. After coagulation (1, 4 and 28 days), the retinas were stained for GABA, using a direct biotinavidin-horseradish peroxidase immunocytochemical method. These time intervals were chosen with regard to the existing knowledge of retinal repair. The staining for GABA was increased in the inner plexiform layer at the centre of the lesions at days 1 and 4 after coagulation. At the margins of the lesions, cells in the ganglion cell layer showed strong staining and cells in the amacrine cell layer showed cuffing, independent of the wavelength used. On day 28, a regression of the hyperstaining was noted. Some possible pathophysiological mechanisms are discussed.
- Subjects :
- Pathology
medicine.medical_specialty
Time Factors
genetic structures
Immunocytochemistry
Light Coagulation
Biology
Retina
gamma-Aminobutyric acid
Amacrine cell
Cellular and Molecular Neuroscience
chemistry.chemical_compound
medicine
Animals
Ganglion cell layer
gamma-Aminobutyric Acid
Staining and Labeling
Lasers
Retinal
Inner plexiform layer
Immunohistochemistry
Sensory Systems
Staining
Ophthalmology
medicine.anatomical_structure
chemistry
Rabbits
sense organs
medicine.drug
Subjects
Details
- ISSN :
- 00144835
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Experimental Eye Research
- Accession number :
- edsair.doi.dedup.....247cf895874b9f9639f46da342ea959a