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A validated model for prediction of survival to 6 months in patients with trisomy 13 and 18
- Source :
- American Journal of Medical Genetics Part A. 185:806-813
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Congenital heart disease is exceedingly prevalent in trisomy 13 and 18. Improved survival following congenital heart surgery has been reported, however, mortality remains significantly elevated. Utilizing inpatient data on trisomy 13 and 18 from the 2003-2016 Pediatric Health Information System database, a survival model was developed and validated using data from the California Perinatal Quality Care Collaborative and the California Office of Statewide Health Planning and Development. The study cohort included 1,761 infants with trisomy 13 and 18. Two models predicting survival to 6 months of age were developed and tested. The initial model performed excellently, with a c-statistic of 0.87 and a c-statistic of 0.76 in the validation cohort. After excluding procedures performed on the day of death, the revised model's c-statistic was 0.76. Certain variables, including cardiac surgery, gastrostomy, parenteral nutrition, and mechanical ventilation, are predictive of survival to 6 months of age. This study presents a model, which potentially can inform decision-making regarding congenital heart surgery.
- Subjects :
- Heart Defects, Congenital
Male
Pediatrics
medicine.medical_specialty
Trisomy 13 Syndrome
Heart disease
medicine.medical_treatment
Risk Factors
Genetics
medicine
Humans
Cardiac Surgical Procedures
Genetics (clinical)
Survival analysis
Retrospective Studies
Mechanical ventilation
Models, Statistical
business.industry
Infant, Newborn
Length of Stay
Prognosis
medicine.disease
Gastrostomy
Cardiac surgery
Survival Rate
Parenteral nutrition
Cohort
Female
Trisomy
business
Trisomy 18 Syndrome
Follow-Up Studies
Subjects
Details
- ISSN :
- 15524833 and 15524825
- Volume :
- 185
- Database :
- OpenAIRE
- Journal :
- American Journal of Medical Genetics Part A
- Accession number :
- edsair.doi.dedup.....247c483a9abeac5686a276936d01d1d4