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Pneumococcal surface protein C contributes to sepsis caused by Streptococcus pneumoniae in mice
- Publication Year :
- 2004
-
Abstract
- The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal dose up to 250-fold higher than that for the wild type. Our findings indicate that PspC affords a decisive contribution to sepsis development.
- Subjects :
- DNA, Bacterial
Ratón
Immunology
Mutant
Biology
medicine.disease_cause
Microbiology
Pneumococcal Infections
Sepsis
Mice
Bacterial Proteins
Immunity
Streptococcus pneumoniae
medicine
Animals
Base Sequence
Virulence
Lethal dose
Wild type
Bacterial Infections
medicine.disease
Streptococcaceae
biology.organism_classification
infection
Infectious Diseases
Genes, Bacterial
Mutation
Mice, Inbred CBA
Parasitology
Gene Deletion
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....247420f99f873f996514c1d0f9c146cf