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A PINK1-mediated mitophagy pathway decides the fate of tumors—to be benign or malignant?
- Publication Year :
- 2018
- Publisher :
- Taylor & Francis, 2018.
-
Abstract
- Macroautophagy/autophagy plays a dual role in cancer depending on the stage of tumorigenesis. Autophagy prevents tumor initiation by suppressing chronic tissue damage, inflammation, accumulation of damaged organelles and genome instability. Autophagy can also sustain tumor metabolism and provide nutrients for tumor growth and survival via nutrient recycling. Moreover, autophagy is required for benign tumors to progress to malignant tumors. Emerging evidence indicates that autophagy or mitophagy can inactivate tumor suppressors such as TP53/TRP53/p53 to promote tumor progression once carcinogenesis has been initiated.
- Subjects :
- 0301 basic medicine
Genome instability
Editor's Corner
Carcinogenesis
PINK1
Tumor initiation
Biology
medicine.disease_cause
03 medical and health sciences
Neoplasms
Mitophagy
medicine
Autophagy
Humans
Molecular Biology
Cancer
Cell Biology
medicine.disease
Mitochondria
030104 developmental biology
Tumor progression
Cancer research
Tumor Suppressor Protein p53
Protein Kinases
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2465e5c052361442df8a8f6428e58e44