Figure S6 from RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis

Figure S6. A Smurf1-dependency of RASSF1A suppression of RhoA-driven metastasis. A, The NOD/SCID mice were injected intravenously with A549-pcDNA or A549-RhoA (G14V) cells, which carry either shControl or shSmurf1 constructs. Metastatic nodules in the lungs were counted macroscopically after 20 days post-injection. Data represent the mean {plus minus} SD (n = 5 per group; **, P < 0.01).