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Lactate shuttle: from substance exchange to regulatory mechanism
- Source :
- Human Cell. 35:1-14
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Lactate, as the product of glycolytic metabolism and the substrate of energy metabolism, is an intermediate link between cancer cell and tumor microenvironment metabolism. The exchange of lactate between the two cells via mono-carboxylate transporters (MCTs) is known as the lactate shuttle in cancer. Lactate shuttle is the core of cancer cell metabolic reprogramming between two cells such as aerobic cancer cells and hypoxic cancer cells, tumor cells and stromal cells, cancer cells and vascular endothelial cells. Cancer cells absorb lactate by mono-carboxylate transporter 1 (MCT1) and convert lactate to pyruvate via intracellular lactate dehydrogenase B (LDH-B) to maintain their growth and metabolism. Since lactate shuttle may play a critical role in energy metabolism of cancer cells, components related to lactate shuttle may be a crucial target for tumor antimetabolic therapy. In this review, we describe the lactate shuttle in terms of both substance exchange and regulatory mechanisms in cancer. Meanwhile, we summarize the difference of key proteins of lactate shuttle in common types of cancer.
- Subjects :
- Monocarboxylic Acid Transporters
Cancer Research
Stromal cell
Neoplasms
Pyruvic Acid
Tumor Microenvironment
medicine
Humans
Glycolysis
Molecular Targeted Therapy
Tumor microenvironment
L-Lactate Dehydrogenase
Symporters
Chemistry
Endothelial Cells
Cancer
Cell Biology
Metabolism
medicine.disease
Cell biology
Isoenzymes
Cancer cell
Lactates
Stromal Cells
Stem cell
Energy Metabolism
Intracellular
Subjects
Details
- ISSN :
- 17490774
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Human Cell
- Accession number :
- edsair.doi.dedup.....2453af9d5bc61eb4d6ba18da23e8a5fd