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Expressions of insulin-like growth factor receptor-1 and cezanne-1 in lung adenocarcinoma
- Source :
- Medical Oncology. 34
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- IGF1R (insulin-like growth factor receptor-1) was confirmed to play a significant role in the development of cancer. Cezanne-1 overexpression was considered to be associated with enhancement of EGFR signaling pathway and reduced degeneration of EGFR. There was a close relationship between EGFR and IGFR as previous study showed. Dynamic balance between receptor ubiquitination and deubiquitination was critical in the process of termination of IGF signaling pathway. So we conducted an IHC staining to initially prove the correlation. Cezanne-1 and IGF1R expressions were evaluated in 103 patients with lung adenocarcinoma using immunohistochemical (IHC) analysis. The relationship between expressions of cezanne-1 and IGF1R were analyzed by χ2 test. Kaplan-Meier method was used to generate the survival curve, and the statistical difference was calculated by log-rank test. We also used data in R2 system to verify the relationship between IGF1R and cezanne-1. R2 system showed there was a close correlation between IGF1R and cezanne-1. Positive expression of cezanne-1 was detected in 64.1% patients. A significant association was shown between cezanne-1 and IGF1R expression (p
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
Adenocarcinoma of Lung
Adenocarcinoma
Insulin-Like Growth Factor Receptor
Biology
Receptor, IGF Type 1
03 medical and health sciences
0302 clinical medicine
Internal medicine
Endopeptidases
medicine
Humans
Receptor
Survival analysis
Aged
Insulin-like growth factor 1 receptor
Growth factor
Cancer
Receptors, Somatomedin
Hematology
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
body regions
030104 developmental biology
Endocrinology
030220 oncology & carcinogenesis
Female
Subjects
Details
- ISSN :
- 1559131X and 13570560
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Medical Oncology
- Accession number :
- edsair.doi.dedup.....244dd31bc9c06d427bfb4698813f0cba