Back to Search
Start Over
Portable ultraviolet light A1 light source to treat hypertrophic scar
- Source :
- Dermatologica Sinica, Vol 33, Iss 1, Pp 11-15 (2015)
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Background/Objectives Recently, fibrotic diseases such as hypertrophic scar, keloid, and scleroderma have been treated with UV-A1 radiation with encouraging results. However, conventional UV light sources are bulky and expensive. In this study, we aimed to verify the effectiveness of a portable UV-A1 radiation device in treating hypertrophic scars. Materials and methods A light-emitting diode array that emitted 365 ± 5 nm (UV-A1) was used to irradiate fibroblasts and hypertrophic scar in a rabbit model. Results In cell cultures, UV-A1 light exposure inhibited post-wound cell migration and reduced the total amount of soluble collagen production in fibroblasts. Type I collagenase production and its activity increased after treatment. On the rabbit ear, UV-A1 light irradiation reduced the thickness of hypertrophic scars, confirming the antifibrotic effect in vivo. Conclusion These results support the potential of a portable UV-A1 light device in treating hypertrophic scar.
- Subjects :
- Pathology
medicine.medical_specialty
business.industry
fibrosis
Light irradiation
Cell migration
Dermatology
lcsh:RL1-803
medicine.disease
scar
UV-A1
Hypertrophic scar
Light source
Keloid
Fibrosis
Ultraviolet light
Collagenase
lcsh:Dermatology
Medicine
light-emitting diode
business
medicine.drug
phototherapy
Subjects
Details
- ISSN :
- 10278117
- Volume :
- 33
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Dermatologica Sinica
- Accession number :
- edsair.doi.dedup.....244d681deac89d2456f2fb04295b105b
- Full Text :
- https://doi.org/10.1016/j.dsi.2014.10.001