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Computed Tomography Radiomics Kinetics as Early Imaging Correlates of Osteoradionecrosis in Oropharyngeal Cancer Patients
- Source :
- Frontiers in Artificial Intelligence, Frontiers in Artificial Intelligence, Vol 4 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Osteoradionecrosis (ORN) is a major side-effect of radiation therapy in oropharyngeal cancer (OPC) patients. In this study, we demonstrate that early prediction of ORN is possible by analyzing the temporal evolution of mandibular subvolumes receiving radiation. For our analysis, we use computed tomography (CT) scans from 21 OPC patients treated with Intensity Modulated Radiation Therapy (IMRT) with subsequent radiographically-proven ≥ grade II ORN, at three different time points: pre-IMRT, 2-months, and 6-months post-IMRT. For each patient, radiomic features were extracted from a mandibular subvolume that developed ORN and a control subvolume that received the same dose but did not develop ORN. We used a Multivariate Functional Principal Component Analysis (MFPCA) approach to characterize the temporal trajectories of these features. The proposed MFPCA model performs the best at classifying ORN vs. Control subvolumes with an area under curve (AUC) = 0.74 [95% confidence interval (C.I.): 0.61–0.90], significantly outperforming existing approaches such as a pre-IMRT features model or a delta model based on changes at intermediate time points, i.e., at 2- and 6-month follow-up. This suggests that temporal trajectories of radiomics features derived from sequential pre- and post-RT CT scans can provide markers that are correlates of RT-induced mandibular injury, and consequently aid in earlier management of ORN.
- Subjects :
- medicine.medical_specialty
longitudinal
Osteoradionecrosis
oropharyngeal cancer
medicine.medical_treatment
Computed tomography
01 natural sciences
lcsh:QA75.5-76.95
030218 nuclear medicine & medical imaging
010104 statistics & probability
03 medical and health sciences
0302 clinical medicine
Radiomics
Artificial Intelligence
Early prediction
medicine
osteoradionecrosis
0101 mathematics
radiotherapy
Uncategorized
Original Research
functional principal component analysis
medicine.diagnostic_test
business.industry
Head and neck cancer
Cancer
computed tomography
medicine.disease
Confidence interval
Radiation therapy
stomatognathic diseases
radiomics
head and neck cancer
Radiology
lcsh:Electronic computers. Computer science
sense organs
business
Subjects
Details
- Language :
- English
- ISSN :
- 26248212
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Frontiers in Artificial Intelligence
- Accession number :
- edsair.doi.dedup.....244bdeab0be23d0f484d091ea1daca58