Back to Search
Start Over
Longitudinal Risk of Herpes Simplex Virus (HSV) Type 1, HSV Type 2, and Cytomegalovirus Infections among Young Adolescent Girls
- Source :
- Clinical Infectious Diseases. 39:1433-1438
- Publication Year :
- 2004
- Publisher :
- Oxford University Press (OUP), 2004.
-
Abstract
- Background Cross-sectional seroprevalence studies indicate that infections with herpes simplex virus (HSV) types 1 (HSV-1) and 2 (HSV-2) and cytomegalovirus (CMV) are common. However, data on the rates of acquisition of these infections are limited. Methods A 3-year longitudinal study of HSV-1, HSV-2, and CMV seroprevalence was conducted in a cohort of 174 adolescent girls (age at enrollment, 12-15 years). Results At study entry, 41% of the girls reported a history of sexual activity, and by the end of the study, 73% reported a history of sexual activity. At enrollment, 71% of all participants were seropositive for CMV, 44% were seropositive for HSV-1, and 7% were seropositive for HSV-2. By the end of the study, 81% of the girls were seropositive for CMV, 49% were seropositive for HSV-1, and 14% were seropositive for HSV-2. Among girls with a history of sexual activity, 15.5% were HSV-2 seropositive at the beginning of the study, and 18.9% were HSV-2 seropositive at the end of the study. The attack rates, based on the number of cases per 100 person-years, were 13.8 for CMV infection and 3.2 for HSV-1 infection (among all girls) and 4.4 for HSV-2 infection (among girls with a history of sexual activity). Participants with preexisting HSV-1 antibodies were associated with a significantly lower attack rate for HSV-2 infection. A generalized estimating equation model indicated that participants with a longer history of sexual activity and those who had more sexually transmitted diseases during the 6-month periods before the study visits were more likely to be HSV-2 seropositive. Conclusions This longitudinal study of adolescent girls found high baseline CMV and HSV-1 seroprevalence rates and substantial attack rates for all 3 pathogens.
- Subjects :
- Microbiology (medical)
Sexually transmitted disease
Human cytomegalovirus
Pediatrics
medicine.medical_specialty
Longitudinal study
Adolescent
Urban Population
Cross-sectional study
Herpesvirus 2, Human
viruses
Attack rate
Herpesvirus 1, Human
Risk Factors
Seroepidemiologic Studies
medicine
Humans
Seroprevalence
Longitudinal Studies
Risk factor
Child
Herpes Genitalis
business.industry
Herpes Simplex
medicine.disease
Infectious Diseases
Cytomegalovirus Infections
Cohort
Immunology
Female
business
Subjects
Details
- ISSN :
- 15376591 and 10584838
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....243f1cbe4a873b92df301f52370fb4f0