Diagnostic improvement of prostate cancer using an extensive biopsy protocol

Seventy patients (mean age: 66.5 69 y) were submitted to TRUS-guided prostate biopsies for increased prostate speci®c antigen (PSA> 4 ng=ml). Mean PSA was 10.5 10.9 ng=ml. In this new protocol, ®ve biopsies were performed in each lobe. Beside the three standard biopsies (taken at 45 angle), two additional biopsies (one at the base and one at the mid-lobe) were taken at a 30 angle sampling the peripheral zone. An additional peripheral biopsy was taken at the apex if there was a prostate volume> 50 cm. This biopsy protocol took place on an outpatient basis. Results