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Anti-interleukin-3 and anti-nerve growth factor increase neonatal mice survival to reovirus type 3 clone 9 per oral challenge
- Source :
- Journal of neuroimmunology. 110(1-2)
- Publication Year :
- 2000
-
Abstract
- Reovirus type 3 clone 9 (T3C9) induces lethal encephalitis in neonatal, but not adult mice. Whether host factors that promote the development and/or functioning of nervous and gastrointestinal tissues could modulate the pathogenesis of this enteric virus was examined. The results showed that antibody specific for interleukin-3 or nerve growth factor antiserum, but not anti-interleukin-6 or anti-tumor necrosis factor-α/β increased mice survival to T3C9 and decreased viral titers in nervous tissues early after infection. These data suggest that IL-3 and NGF are involved in the pathogenesis of T3C9 infection in neonatal mice.
- Subjects :
- Central Nervous System
Necrosis
Immunology
Clone (cell biology)
Biology
Antibodies
Pathogenesis
Mice
Nerve Growth Factor
medicine
Immunology and Allergy
Animals
Encephalitis, Viral
Mammalian orthoreovirus 3
Interleukin 3
Antiserum
Interleukin-6
Tumor Necrosis Factor-alpha
Age Factors
medicine.disease
Survival Analysis
Reoviridae Infections
Methylene Blue
Nerve growth factor
Neurology
Animals, Newborn
biology.protein
Interleukin-3
Neurology (clinical)
medicine.symptom
Antibody
Encephalitis
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 110
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Journal of neuroimmunology
- Accession number :
- edsair.doi.dedup.....2434c6f410e498087a3c6fda09e2493a