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Longitudinal trends and determinants of patient-reported side effects on ART-a Swedish national registry study
- Source :
- PLoS ONE, Vol 15, Iss 12, p e0242710 (2020), PLoS ONE
- Publication Year :
- 2020
- Publisher :
- PLOS, 2020.
-
Abstract
- Introduction The use of patient-reported outcomes (PROs) to systematically quantify adverse events (AE) will assist in the improvement of medical care and the QoL of patients living with HIV (PLWH). The aim of this study was to investigate the associations between self-reported side effects and other PROs, demographics and laboratory data, and further evaluate the Health Questionnaire (HQ) as a tool for following trends in patient-reported side effects over time in relation to trends in prescribed third agent in ART. Materials and methods The Swedish National Registry InfCareHiv includes an annual self-reported nine-item HQwhich is used in patient-centered HIV care in all Swedish HIV units. In this study, the experience of side effects was addressed. We analyzed 9,476 HQs completed by 4,186 PLWH together with details about their prescribed ART and relevant biomarkers collected during 2011–2017. Data were analyzed using descriptive statistics, Pearson’s correlation coefficient and mixed logistic regression. Results The cross-sectional analysis of the HQs showed that the frequency of reported side effects decreased from 32% (2011) to 15% (2017). During the same period, there was a shift in ART prescription from efavirenz (EFV) to dolutegravir (DTG) (positive correlation coefficient r = 0.94, p = 0.0016). Further, PLWH who reported being satisfied with their physical health (OR: 0.47, p = Conclusions Self-reported side effects were found to have a close relationship with the patient’s ratings of their overall health situation and demonstrated a strong correlation with the sharp decline in use of EFV and rise in use of DTG, with reported side effects being halved. This study supports the feasibility of using the HQ as a tool for longitudinal follow up of trends in PROs.
- Subjects :
- RNA viruses
Cyclopropanes
Male
Physiology
HIV Infections
Pathology and Laboratory Medicine
Logistic regression
Geographical locations
Piperazines
chemistry.chemical_compound
0302 clinical medicine
Immunodeficiency Viruses
Erectile Dysfunction
Antiretroviral Therapy, Highly Active
Medicine and Health Sciences
Medicine
Public and Occupational Health
Longitudinal Studies
Registries
030212 general & internal medicine
Multidisciplinary
HIV diagnosis and management
Nausea
Middle Aged
Vaccination and Immunization
Arthralgia
Body Fluids
Europe
Blood
Medical Microbiology
Research Design
Viral Pathogens
Alkynes
Viruses
Dolutegravir
Female
Pathogens
Anatomy
0305 other medical science
Heterocyclic Compounds, 3-Ring
Research Article
Adult
Efavirenz
Clinical Research Design
Anti-HIV Agents
Pyridones
Science
Immunology
MEDLINE
Antiretroviral Therapy
Research and Analysis Methods
Microbiology
RT
03 medical and health sciences
Adverse Reactions
Antiviral Therapy
Retroviruses
Mental Health and Psychiatry
Oxazines
Humans
European Union
Patient Reported Outcome Measures
Medical prescription
Adverse effect
Microbial Pathogens
Pharmacology
Sweden
030505 public health
Descriptive statistics
business.industry
Lentivirus
Organisms
Biology and Life Sciences
HIV
Diagnostic medicine
Benzoxazines
Blood Counts
Cross-Sectional Studies
chemistry
Quality of Life
Preventive Medicine
Adverse Events
National registry
People and places
business
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, Vol 15, Iss 12, p e0242710 (2020), PLoS ONE
- Accession number :
- edsair.doi.dedup.....2434be7176b439b04ed0d4383fecf1d3