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Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd
- Source :
- Contrast Media & Molecular Imaging, Vol 2018 (2018), Contrast Media & Molecular Imaging
- Publication Year :
- 2018
- Publisher :
- Hindawi-Wiley, 2018.
-
Abstract
- Tumor cell complete extinction is a crucial measure to evaluate antitumor efficacy. The difficulties in defining tumor margins and finding satellite metastases are the reason for tumor recurrence. A synergistic method based on multimodality molecular imaging needs to be developed so as to achieve the complete extinction of the tumor cells. In this study, graphene oxide conjugated with gold nanostars and chelated with Gd through 1,4,7,10-tetraazacyclododecane-N,N′,N,N′-tetraacetic acid (DOTA) (GO-AuNS-DOTA-Gd) were prepared to target HCC-LM3-fLuc cells and used for therapy. For subcutaneous tumor, multimodality molecular imaging including photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) and the related processing techniques were used to monitor the pharmacokinetics process of GO-AuNS-DOTA-Gd in order to determine the optimal time for treatment. For orthotopic tumor, MRI was used to delineate the tumor location and margin in vivo before treatment. Then handheld photoacoustic imaging system was used to determine the tumor location during the surgery and guided the photothermal therapy. The experiment result based on orthotopic tumor demonstrated that this synergistic method could effectively reduce tumor residual and satellite metastases by 85.71% compared with the routine photothermal method without handheld PAI guidance. These results indicate that this multimodality molecular imaging-guided photothermal therapy method is promising with a good prospect in clinical application.
- Subjects :
- Carcinoma, Hepatocellular
Materials science
lcsh:Medical technology
Article Subject
Metal Nanoparticles
Gadolinium
02 engineering and technology
Conjugated system
010402 general chemistry
01 natural sciences
Mice
chemistry.chemical_compound
Liver Neoplasms, Experimental
In vivo
Cell Line, Tumor
medicine
Animals
Humans
DOTA
Radiology, Nuclear Medicine and imaging
Chelation
Chelating Agents
Mice, Inbred BALB C
medicine.diagnostic_test
Magnetic resonance imaging
Hyperthermia, Induced
Phototherapy
Photothermal therapy
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
0104 chemical sciences
chemistry
lcsh:R855-855.5
Colloidal gold
Graphite
Gold
Molecular imaging
0210 nano-technology
Research Article
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 15554317 and 15554309
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Contrast Media & Molecular Imaging
- Accession number :
- edsair.doi.dedup.....24335ef7cd84ef3bb8bedf1df410bc2a