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Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd

Authors :
Dong Peng
Yushen Jin
Xibo Ma
Jie Tian
Shoushui Wei
Yi Wang
Shuai Zhang
Wei Chai
Xuejun Li
Xin Yang
Source :
Contrast Media & Molecular Imaging, Vol 2018 (2018), Contrast Media & Molecular Imaging
Publication Year :
2018
Publisher :
Hindawi-Wiley, 2018.

Abstract

Tumor cell complete extinction is a crucial measure to evaluate antitumor efficacy. The difficulties in defining tumor margins and finding satellite metastases are the reason for tumor recurrence. A synergistic method based on multimodality molecular imaging needs to be developed so as to achieve the complete extinction of the tumor cells. In this study, graphene oxide conjugated with gold nanostars and chelated with Gd through 1,4,7,10-tetraazacyclododecane-N,N′,N,N′-tetraacetic acid (DOTA) (GO-AuNS-DOTA-Gd) were prepared to target HCC-LM3-fLuc cells and used for therapy. For subcutaneous tumor, multimodality molecular imaging including photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) and the related processing techniques were used to monitor the pharmacokinetics process of GO-AuNS-DOTA-Gd in order to determine the optimal time for treatment. For orthotopic tumor, MRI was used to delineate the tumor location and margin in vivo before treatment. Then handheld photoacoustic imaging system was used to determine the tumor location during the surgery and guided the photothermal therapy. The experiment result based on orthotopic tumor demonstrated that this synergistic method could effectively reduce tumor residual and satellite metastases by 85.71% compared with the routine photothermal method without handheld PAI guidance. These results indicate that this multimodality molecular imaging-guided photothermal therapy method is promising with a good prospect in clinical application.

Details

Language :
English
ISSN :
15554317 and 15554309
Volume :
2018
Database :
OpenAIRE
Journal :
Contrast Media & Molecular Imaging
Accession number :
edsair.doi.dedup.....24335ef7cd84ef3bb8bedf1df410bc2a