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Functional Connectivity Networks in Nonbothersome Tinnitus
- Source :
- Otolaryngology–Head and Neck Surgery. 147
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- To assess functional connectivity in cortical networks in patients with nonbothersome tinnitus compared with a normal healthy nontinnitus control group by measuring low-frequency (0.1 Hz) spontaneous blood oxygenation level-dependent (BOLD) signals at rest.Case-control.Academic medical center.Nonbothersome, idiopathic subjective tinnitus for at least 6 months (n = 18) and a normal healthy nontinnitus control group (n = 23).Functional connectivity differences in 58 a priori selected seed regions of interest encompassing cortical loci in the default mode, attention, auditory, visual, somatosensory, and cognitive networks.The median age of the 18 subjects was 54 years (interquartile range [IQR], 52-57), 66% were male, 90% were white, median Tinnitus Handicap Inventory (THI) score was 8 (IQR, 4-14), and a median Beck Depression Index score was 1 (IQR, 0-5). The median age for the control group was 46 years (IQR, 39-54), and 52% were male. Of the 58 seeds analyzed, no regions had significantly different functional connectivity among the nonbothersome tinnitus group when compared with the control group.Among nonbothersome tinnitus patients, the tinnitus percept does not appear to alter the functional connectivity of the auditory cortex or other key cortical regions. Trial Registration ClinicalTrials.gov Identifier: NCT01049828.
- Subjects :
- Male
medicine.medical_specialty
Audiology
Article
Tinnitus
Interquartile range
medicine
otorhinolaryngologic diseases
Humans
In patient
Default mode network
Depression (differential diagnoses)
Auditory Cortex
business.industry
Functional connectivity
Middle Aged
Index score
Otorhinolaryngology
Case-Control Studies
Blood oxygenation
Female
Surgery
medicine.symptom
Nerve Net
business
Subjects
Details
- ISSN :
- 10976817, 01945998, and 01049828
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- Otolaryngology–Head and Neck Surgery
- Accession number :
- edsair.doi.dedup.....242b7d56b21c5d2ecd0976ae7b0f812b