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Direct Asymmetric Reductive Amination of Alkyl (Hetero)Aryl Ketones by an Engineered Amine Dehydrogenase
- Source :
- Angewandte Chemie International Edition. 61
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- The direct asymmetric reductive amination of heteroaryl ketones has been a long-standing synthetic challenge. Here we report the engineering of an amine dehydrogenase (AmDH) from Jeotgalicoccus aerolatus for the asymmetric synthesis of chiral α-(hetero)aryl primary amines in excellent conversions (up to 99 %) and enantioselectivities (up to 99 % ee). The best AmDH variant (Ja-AmDH-M3
Details
- ISSN :
- 15213773 and 14337851
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi.dedup.....240bce84b65092dc996f17c6986e4941