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Autophagy as a Neuroprotective Mechanism Against 3-Nitropropionic Acid-Induced Murine Astrocyte Cell Death
- Source :
- Neurochemical Research. 38:2418-2426
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Huntington's disease (HD) is a genetic neurodegenerative disorder that is characterized by severe striatal atrophy with extensive neuronal loss and gliosis. Although the molecular mechanism is not well understood, experimental studies use the irreversible mitochondrial inhibitor 3-nitropropionic acid (3-NP) to mimic the neuropathological features of HD. In this study, the role of autophagy as a neuroprotective mechanism against 3-NP-induced astrocyte cytotoxicity was evaluated. Autophagy is a catabolic process that is essential for the turnover of cytosolic proteins and organelles and is involved in the modulation of cell death and survival. We showed that 3-NP-induced apoptosis, which was accompanied by Bax and Beclin-1 upregulation, was dependent on acidic vesicular organelle (AVO) formation after a continuous exposure to 3-NP for 12 h. The upregulation of Bax and Beclin-1 as well as AVO formation were normalized 24 h after 3-NP exposure.
- Subjects :
- Programmed cell death
Apoptosis
Biology
Biochemistry
Neuroprotection
Mice
Cellular and Molecular Neuroscience
Downregulation and upregulation
Huntington's disease
Autophagy
medicine
Animals
bcl-2-Associated X Protein
Sirolimus
Adenine
General Medicine
Nitro Compounds
medicine.disease
Cell biology
Disease Models, Animal
Huntington Disease
medicine.anatomical_structure
Gliosis
Astrocytes
Beclin-1
Propionates
medicine.symptom
Apoptosis Regulatory Proteins
Astrocyte
Subjects
Details
- ISSN :
- 15736903 and 03643190
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Neurochemical Research
- Accession number :
- edsair.doi.dedup.....240306918c175bfc04b3247f6b069c4d