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Novel gene identified in an exome-wide association study of tanning dependence
- Source :
- Experimental Dermatology. 23:757-759
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Growing evidence suggests that some individuals may exhibit symptoms of dependence to ultraviolet light, a known carcinogen, in the context of tanning. Genetic associations with tanning dependence (TD) have not yet been explored. We conducted an exome-wide association study in 79 individuals who exhibited symptoms of TD and 213 individuals with volitional exposure to ultraviolet light, but who were not TD based on three TD scales. A total of 300 000 mostly exomic single nucleotide polymorphisms primarily in coding regions were assessed using an Affymetrix Axiom array. We performed a gene burden test with Bonferroni correction for the number of genes examined (P 0.05/14 904 = 3.36 × 10(-6) ). One gene, patched domain containing 2 (PTCHD2), yielded a statistically significant P-value of 2.5 × 10(-6) (OR = 0.27) with fewer individuals classified as TD having a minor allele at this locus. These results require replication, but are the first to support a specific genetic association with TD.
- Subjects :
- Neoplasms, Radiation-Induced
Skin Neoplasms
Single-nucleotide polymorphism
Locus (genetics)
Dermatology
Biology
Polymorphism, Single Nucleotide
Biochemistry
Article
visual_art.visual_artist
Sunbathing
Risk Factors
Ultraviolet light
medicine
Humans
Allele
Molecular Biology
Alleles
Genetic Association Studies
Genetic association
Suntan
Genetics
Mental Disorders
Membrane Proteins
Exons
Minor allele frequency
Carcinoma, Basal Cell
Case-Control Studies
visual_art
Tanning dependence
medicine.symptom
Subjects
Details
- ISSN :
- 09066705
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Experimental Dermatology
- Accession number :
- edsair.doi.dedup.....23ef4c5e233366db061ac060cd1cd648