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Early small creatinine shift predicts contrast-induced acute kidney injury and persistent renal damage after percutaneous coronary procedures
- Publication Year :
- 2020
-
Abstract
- Little is known on the impact of contrast-induced acute kidney injury (CI-AKI) on mid- and long-term renal function after percutaneous coronary procedure. The aim of the study was to investigate the incidence of persistent renal damage (PRD) after CI-AKI in a cohort of patients undergoing coronary angiography and/or intervention. Moreover, we sought to assess the predictive value of small creatinine change at 12-24 h (SCrΔ%12-24 h) from contrast exposure in predicting CI-AKI and PRD.Complete clinical and biochemical data of 731 patients were retrospectively analyzed at sequential time intervals at baseline, 12-24 h and 48-72 h from the procedure. Data at 30 ± 10 days and 12-24 months were available in 59% and 49% of the cases respectively. Logistic regression was used to assess variables associated with CI-AKI and PRD. ROC analysis was used to test the diagnostic accuracy of SCrΔ%12-24 h in predicting CI-AKI and PRD.CI-AKI occurred in 130/731 patients (17.8%). At 30 ± 10 days PRD occurred in 54.8% patients who developed CI-AKI. A SCrΔ%12-24 h5% demonstrated independent predictive value (OR = 1.05, CI = 1.04-1.06, p 0.001) and fair accuracy (AUC = 0.80, CI = 0.77-0.84) for CI-AKI.CI-AKI was associated with PRD in50% of the cases in this single centre cohort. A small and early SCrΔ%12-24 h demonstrated high predictive value for CI-AKI and may be used as a useful tool to unmask a group of patients at risk for PRD after percutaneous coronary procedures.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Percutaneous
medicine.medical_treatment
Coronary angiography
Contrast-induced nephropathy
Contrast Media
Renal function
030204 cardiovascular system & hematology
Kidney
Radiography, Interventional
urologic and male genital diseases
Percutaneous coronary intervention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
medicine
Humans
030212 general & internal medicine
Contrast-induced acute kidney injury
Aged
Retrospective Studies
Aged, 80 and over
Creatinine
business.industry
Incidence (epidemiology)
Acute kidney injury
General Medicine
Acute Kidney Injury
Middle Aged
medicine.disease
Treatment Outcome
chemistry
Cohort
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....23ec9696d09a1b93bc0425c9ecd1e884